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1981, in Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid, and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid. Supplementing with tryptophan helps support serotonin synthesis, especially when dietary intake is insufficient

In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure